On television, Sheryl Lee has starred in It's a Living, her own series New Attitude, the George Foreman series George and in the hit comedy Designing Women. She was also voted one of TV's Favorite Moms for her portrayal of step mom Dee on the number-one rated television series Moesha. She broke new ground In the SHOWTIME series, Barbershop, as the popular, post-operative transsexual, Claire. Recently, Sheryl brought a new face to the sufferings of war in the NBC hit series ER.

Her extensive film credits include Sister Act II with Whoopi Goldberg, The Flintstones with Rosie O'Donell, The Mighty Quinn with Denzel Washington, Mistress with Robert De Niro, and Eddie Murphy's Distinguished Gentleman. Sheryl Lee's performance with Danny Glover in To Sleep with Anger won her the Independent Spirit Award for Best Supporting Actress.

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